Suzuki-Miyaura HCK1003-01-002

1 set of 8 catalysts (Pd(PPh₃)₄, Pd(dppf)₂Cl₂, PdOAc₂/Sphos, PdOAc₂/Xphos, Pd₂(dba)₂/Sphos, Pd₂(dba)₃/XPhos, Pd(OAc)₂/CataCXium® and Pd(Amphos)Cl₂), 4 base solutions (Na₂CO₃, K₂CO₃, K₃PO₄, and Cs₂CO₃) and 4 solvents Acetonitrile, Dioxane, DMF and n-Butanol. 32 reaction vials total

This kit requires EvoluChem™ reaction block (HCK1006-01-002) included in the EvoluChem™ Starter Kit (HCK1006-01-001)

The typical protocol is performed at 0.15 mol/l concentration reaction condition and 1 to 1 ratio boronic acid reagent and halogenated substrate in 100 μl selected solvent.

Resulting catalyst loading is 10%. Two equivalents of base are added (30 μl). However it is possible to investigate different substrate ratios and concentrations. Maximum volume for reaction condition is 250 μl.

Protocol at 100 μl volume reaction condition

• Prepare required volume of a 0.15 mol/L solution of combined substrates (boronic acid reagent and halogenated substrate) in the selected solvent. For example, 450 μl solution for 4 reaction conditions.
• Using a clean and dry syringe, add 100 μl of substrates solution to a reaction vial and mix with the catalysts using the syringe.
• Add 30 μl of the selected base solution. (2 equivalents)
• Stir the reaction vials in the reaction block at desired temperature (for example: 80°C) for 3 to 12 hours.
• Remove the vial caps using a decapper.
• Prepare analytical sample for each reaction condition with 5 μl sample diluted into 200 μl in either DMSO or water/acetonitrile 50/50. Analyze resulting analytical samples by LC/MS.