Photoredox chemistry has been reported in the literature using a wide range of catalysts and reagents. However, often these reactions are highly substrate, solvent and base specific. In order to facilitate the screening of common photochemistry reactions, HepatoChem has released a series of high-throughput photochemistry screening kits combining common Iridium, Nickel, ligand and base combinations to achieve successful cross-coupling transformations.
Ir/Ni catalysis versatility
Depending on the ligand, base and solvent, the Ir/Ni catalytic systems can perform different cross-coupling reaction.
C-C Coupling
C-N Coupling
C-O Coupling
6 Ir/Ni Kits Available
Ir/Ni Base and Solvent Kit
2 sets of 8 conditions with 8 different bases per kit (16 total vials)
5 µmol of substrates in 100 µl solvent, Ir(dF-CF3-ppy)3(dtbbpy)PF6 (2 mol%), Ni Ligand dtbbpy (10 mol%) and base (3 eq.)
Ir/Ni Base and Ligand Screen Kit 1
2 sets of 16 conditions with 4 bases and 4 ligands per kit (32 total vials)
5 µmol of substrates in 100 µl solvent, Ir(dF-CF3-ppy)3(dtbbpy)PF6 (2 mol%), Ni Ligand dtbbpy (10 mol%) and base (3 eq.)
Ir/Ni Base and Ligand Screen Kit 2
2 sets of 24 conditions with 6 bases and 4 ligands per kit (48 total vials)
5 µmol of substrates in 100 µl solvent, Ir(dF-CF3-ppy)3(dtbbpy)PF6 (2 mol%), Ni Ligand dtbbpy (10 mol%) and base (3 eq.)
Ir/Ni Base and Ir Catalyst Screen Kit 1
2 sets of 18 conditions with 3 bases and 6 Ir catalysts per kit (36 total vials)
5 µmol of substrates in 100 µl solvent Ir catalyst (2 mol%), Ni dtbbpy (10 mol%) and base (3 eq.)
Ir/Ni Base and Catalyst Screen Kit for C-O coupling
2 sets of 8 conditions with 4 different bases, Ir(dF-CF3-ppy)2(dtbbpy)PF6
Ni dtbbpy and quinuclidine per kit (16 total vials).
Ir/Ni HAT Screening Kit
3 sets of reaction conditions with iridium catalysts Ir(dF-CF3-ppy)2(dtbbpy)PF6 and Ir(dtbbpy)(ppy)2PF6, NiBr2*3H2O, two ligands 4,7-dOMe-phen and 4,4’-dOMe-bpy and two bases Quinuclidine and 3-Acetoxy-quinuclidine. (15 reaction vials total)
Iridium Catalysts
