Discussion about the modern photochemical approaches using Electron Donor-Acceptor EDA complexes in synthetic organic chemistry.
Electron Donor-Acceptor (EDA) Complexes in Photochemistry
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A Standard Ferrioxalate Actinometer Protocol
We describe ferrioxalate actinometer protocol we use to determine photon flux in different reaction vials and photoreactors.
Determining Photon Flux Using Actinometry
Details on how we determine photon flux using actinometry measurement. Photon flux is measured for our photoreactors using different setups.
Evaluating Light Sources in Photochemistry
Learn how properly evaluating light sources in photochemistry ensures your ability to study, optimize and scale your reactions.
Carbon-Heteroatom Cross-Coupling via an Electronically Excited Nickel (II) Complex
Abstract While carbon-heteroatom cross coupling reactions have been extensively studied, many methods are specific and limited to a set of substrates or functional groups. Reported here is a method that allows for C-O, C-N and C-S cross coupling...
Visible-Light-Induced Trifluoromethylation of Unactivated Alkenes with Tri(9-anthryl)borane as an Organophotocatalyst
Abstract Tri(9-anthryl)borane was successfully applied as an organophotocatalyst for the visible-light-induced trifluoromethylation of unactivated alkenes with CF3I. The mild reaction conditions tolerated a variety of functional groups, and the...
Visible Light Promoted Functionalisation of Carbon-Carbon Sigma Bonds
Abstract The use of visible light to activate transition metal catalysts towards redox processes has transformed the way organic molecules can be constructed. Promotion of an electron to an excited state enables the generation of organic radicals...
Primary α-tertiary amine synthesis via α-C–H functionalization
Abstract A quinone-mediated general synthetic platform for the construction of primary α-tertiary amines from abundant primary α-branched amine starting materials is described. This procedure pivots on the efficientin situgeneration of reactive...
Amide Coupling in Medicinal Chemistry
In recent years, amide coupling has become the most frequently used reaction in medicinal chemistry. However there are numerous reagents available.
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines
Abstract In fragment-based drug discovery (FBDD), a weakly binding fragment hit is elaborated into a potent ligand by bespoke functionalization along specific directions (growth vectors) from the fragment core in order to complement the 3D...
Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines
Abstract A visible-light-mediated photocatalytic umpolung synthesis of 1,3-diamines from in situ-generated imines and dehydroalanine derivatives is described. Pivoting on a key nucleophilic addition of photocatalytically generated α-amino radicals...