Abstract A visible-light-mediated photocatalytic umpolung synthesis of 1,3-diamines from in situ-generated imines and dehydroalanine derivatives is described. Pivoting on a key nucleophilic addition of photocatalytically generated α-amino radicals...
Abstract The sulfoximine group has been reported as a versatile and beneficial functionality for pharmaceutical or agrochemical entities. Herein, we report the Csp2–H sulfoximidation of electron-rich arenes under the irradiation of blue light...
Abstract The selective functionalization of C(sp3)-H bonds at distal positions to functional groups is a challenging task in synthetic chemistry. Reported here is a photoinduced radical cascade strategy for the divergent functionalization of amides...
Abstract A radical deoxychlorination of cesium oxalates has been developed for the preparation of hindered secondary and tertiary alkyl chlorides. The reaction tolerates a number of functional groups, including ketones, alcohols, and amides, and...
Abstract The robust CoIprecatalyst [CpCo(P{OEt}3)(trans"MeO2CHC=CHCO2Me)] was investigated in cyclotrimerizations, furnishing benzenes and pyridines from triynes, diynes and nitriles, comparing the influence of different ways of energy supply;...
Abstract We report herein the facile and one"pot synthesis of α"mono" and di"substituted benzylamines from cheap and readily available α"amino acids, via photocatalytic decarboxylative arylation in flow. This enables to access intermediates and...
Abstract A visible light mediated iridium photocatalysed reverse polarity Povarov reaction of aryl imines and electron deficient alkenes is described. Operatingviaa putative nucleophilic α-amino radical, generated by a proton coupled electron...
Abstract Photoredox decarboxylative cross-coupling via iridium–nickel dual catalysis has emerged as a valuable method for C(sp2)–C(sp3) bond formation. Herein we describe the application of a segmented flow ("microslug") reactor equipped with a...
Abstract Hydroxylamines are found in biologically active compounds and serve as building blocks for the preparation of nitrogen-containing molecules. Here the direct conversion of carboxylic acids into the corresponding alkylhydroxylamines using...
The need for a simple and robust device to perform visible-light photoredox catalysis has become increasingly important. Learn about our setup.
The recent trend of chemical catalysis centers and industry-academia partnerships has led to an influx of new reactions with direct applications for medicinal chemists1. High-throughput experimentation (HTE) approaches have significantly lowered...