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Amide Coupling in Medicinal Chemistry
In recent years, amide coupling has become the most frequently used reaction in medicinal chemistry. However there are numerous reagents available.
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines
Abstract In fragment-based drug discovery (FBDD), a weakly binding fragment hit is elaborated into a potent ligand by bespoke functionalization...
Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines
Abstract A visible-light-mediated photocatalytic umpolung synthesis of 1,3-diamines from in situ-generated imines and dehydroalanine derivatives is...
Late-Stage Sulfoximidation of Electron-Rich Arenes by Photoredox Catalysis
Abstract The sulfoximine group has been reported as a versatile and beneficial functionality for pharmaceutical or agrochemical entities. Herein, we...
Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals
Abstract The selective functionalization of C(sp3)-H bonds at distal positions to functional groups is a challenging task in synthetic chemistry....
Radical Deoxychlorination of Cesium Oxalates for the Synthesis of Alkyl Chlorides
Abstract A radical deoxychlorination of cesium oxalates has been developed for the preparation of hindered secondary and tertiary alkyl chlorides....
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