Abstract The robust CoIprecatalyst [CpCo(P{OEt}3)(trans"MeO2CHC=CHCO2Me)] was investigated in cyclotrimerizations, furnishing benzenes and pyridines from triynes, diynes and nitriles, comparing the influence of different ways of energy supply;...
Abstract We report herein the facile and one"pot synthesis of α"mono" and di"substituted benzylamines from cheap and readily available α"amino acids, via photocatalytic decarboxylative arylation in flow. This enables to access intermediates and...
Abstract A visible light mediated iridium photocatalysed reverse polarity Povarov reaction of aryl imines and electron deficient alkenes is described. Operatingviaa putative nucleophilic α-amino radical, generated by a proton coupled electron...
Abstract Photoredox decarboxylative cross-coupling via iridium–nickel dual catalysis has emerged as a valuable method for C(sp2)–C(sp3) bond formation. Herein we describe the application of a segmented flow ("microslug") reactor equipped with a...
Abstract Hydroxylamines are found in biologically active compounds and serve as building blocks for the preparation of nitrogen-containing molecules. Here the direct conversion of carboxylic acids into the corresponding alkylhydroxylamines using...
The need for a simple and robust device to perform visible-light photoredox catalysis has become increasingly important. Learn about our setup.
The recent trend of chemical catalysis centers and industry-academia partnerships has led to an influx of new reactions with direct applications for medicinal chemists1. High-throughput experimentation (HTE) approaches have significantly lowered...
Salts such as weak bases are omnipresent in organic chemistry. The conversion rate of a reaction can be greatly affected depending on the salt.While it is easy to weigh K2CO3 or Na2CO3. Because salts like Cs2CO3 or K3PO4 are hydroscopic salts, they...
Methyl groups are very common in drug molecules. As reported by Heike Schonherr and Tim Cernak1, more than half of the top-selling drugs contains a CH3. A simple substitution of a C-H with a methyl can increase the potency of a compound by more...
Palladium based catalysis is the most used tool to perform the formation of C-C, C-O and C-N. There are many sources of palladium such as PdOAc2, PdCl2 or Pd2dba3. However the related methods do not always allow sufficient conversion. Palladium...
Dr Ryan Buzdygon will be presenting "Late-stage functionalization platform for lead optimization and diversification: Generation of high value compounds directly for biological testing" at ACS Boston. Stop by on Wednesday August 19th during the...
