Primary \u03b1-tertiary amine synthesis via \u03b1-C\u2013H functionalization<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hepatochem.com\/fr\/primary-%ce%b1-tertiary-amine-synthesis-via-%ce%b1-c-h-functionalization\/\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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{"id":25012,"date":"2019-02-08T17:18:53","date_gmt":"2019-02-09T00:18:53","guid":{"rendered":"https:\/\/hepatochem.com\/primary-%ce%b1-tertiary-amine-synthesis-via-%ce%b1-c-h-functionalization\/"},"modified":"2019-02-08T17:18:53","modified_gmt":"2019-02-09T00:18:53","slug":"primary-%ce%b1-tertiary-amine-synthesis-via-%ce%b1-c-h-functionalization","status":"publish","type":"post","link":"https:\/\/hepatochem.com\/fr\/primary-%ce%b1-tertiary-amine-synthesis-via-%ce%b1-c-h-functionalization\/","title":{"rendered":"Primary \u03b1-tertiary amine synthesis via \u03b1-C\u2013H functionalization"},"content":{"rendered":"

\nAbstract<\/strong><\/p>\n

A quinone-mediated general synthetic platform for the construction of primary \u03b1-tertiary amines from abundant primary \u03b1-branched amine starting materials is described. This procedure pivots on the efficientin $\"\"$ situ<\/em>generation of reactive ketimine intermediates and subsequent reaction with carbon-centered nucleophiles such as organomagnesium and organolithium reagents, and TMSCN, creating quaternary centers. Furthermore, extension to reverse polarity photoredox catalysis enables reactivity with electrophiles,via<\/em>a nucleophilic \u03b1-amino radical intermediate. This efficient, broadly applicable and scalable amine-to-amine synthetic platform was successfully applied to library and API synthesis and in the functionalization of drug molecules.<\/p>\n

Authors:<\/strong> Dhananjayan Vasu<\/a>, $\"ORCID$ <\/a><\/span>^{a<\/i><\/sup><\/span>}Angel L. Fuentes de Arriba<\/a>, $\"ORCID$ <\/a><\/span>^{a<\/i><\/sup><\/span>}Jamie A. Leitch<\/a>, $\"ORCID$ <\/a><\/span>^{a<\/i><\/sup><\/span>}Antoine de Gombert<\/a>^{a<\/i><\/sup>and<\/span>}Darren J. Dixon<\/a> $\"ORCID$ <\/a><\/span>*^{a<\/i><\/sup><\/span><\/p>\n}

Link: <\/strong>https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2019\/sc\/c8sc05164j#!divAbstract<\/a><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"