{"id":24755,"date":"2026-01-14T03:58:43","date_gmt":"2026-01-14T08:58:43","guid":{"rendered":"https:\/\/hepatochem.com\/2025-photochemistry-year-in-review\/"},"modified":"2026-01-14T03:58:43","modified_gmt":"2026-01-14T08:58:43","slug":"2025-photochemistry-year-in-review","status":"publish","type":"post","link":"https:\/\/hepatochem.com\/fr\/2025-photochemistry-year-in-review\/","title":{"rendered":"2025 Photochemistry Year in Review"},"content":{"rendered":"

Our 25 favorite photochemistry papers from 2025<\/h1>\n

\u00a0<\/strong>Happy New Year from all of us at HepatoChem. \u00a0Before we move forward into another great year, let\u2019s take a look back at the past year in photochemistry.\u00a0 \u00a02025 gave us a ton of interesting photochemistry papers, new products, fun ideas and expanded the areas where photochemistry is making an impact.\u00a0 It\u2019s clich\u00e9 to say, but in 2025 it seems there was more photochemistry in the literature than ever before, and this list of our favorite papers gets more difficult to make every year.<\/p>\n

At HepatoChem, we hit a few major milestones and achievements in 2025.\u00a0 Our PhotoRedox products were again cited more than 100 times last year, bringing our total historically over to 500 examples.\u00a0 Unofficially, the 500th mention was perhaps our favorite photochemistry paper to date but of course we\u2019re a bit biased.\u00a0 We are very excited to finally be able to discuss the publication of our own work from a collaboration with Professor Mark Mascal and his team at UC Davis<\/a>.\u00a0 We\u2019ll discuss this JACS<\/em> <\/a>paper in the list below, but it has everything in it, including some exciting Lucent360 experiments, new UV LEDs, a ton of amino acid-based substrates turned into heterocycles and some non-hallucinogenic medically active compounds with the term head-twitch response. \u00a0You can expect to hear more about this work from us in the weeks and months to come.<\/p>\n

This year, we also launched the PhotoRedox Box UV\/vis<\/a>, a photoreactor designed to take advantage of our new dimmable LED options (254 nm to 340 nm) while also allowing visible chemistry up to 850 and 1000 nm (yeah, we have LEDs all the way up to 1000 nm now, but still don\u2019t understand what you oddballs are doing with them).\u00a0 And in 2026, get ready for what might be our favorite new product yet.\u00a0 Coming soon, a new photoreactor that we think just about everyone who reads this email will be able to find a use for.\u00a0 An all-in-one flexible photoreactor for plates, vials, cells culture flasks, petri dishes and more to be placed directly in your incubator, 4\u00b0C fridge, bench or hood.<\/p>\n

And now on to our favorite papers of the past year.\u00a0 We started this little exercise back in 2020 in the depths of COVID and luckily for us now, everything in the current news is much brighter now.\u00a0 Um, moving on.\u00a0\u00a0 Our previous lists can be found here:<\/p>\n

20 papers from 2020<\/strong><\/a><\/span><\/h4>\n

21 papers from 2021<\/strong><\/a><\/span><\/h4>\n

22 papers from 2022<\/strong><\/a><\/span><\/h4>\n

23 papers from 2023<\/strong><\/a><\/span><\/h4>\n

24 papers from 2024<\/strong><\/a><\/span><\/h4>\n

 <\/p>\n

To borrow from our previous lists, we begin with this disclaimer here<\/a>, but this is not an attempt to rank the best 25 papers of the year.\u00a0 What papers are included?\u00a0 Just our favorite, or funniest, or most unexpected or thought-provoking papers that we read last year.\u00a0 A few cite the PhotoRedox Box, TC or Lucent360 products, while others are just our favorite things that we read last year.\u00a0 As always, our lists skews towards papers using photocatalysis for synthesis and if your paper is open access, well that\u2019s a bonus.\u00a0 If your favorite paper isn\u2019t listed then perhaps, we haven\u2019t read it yet or didn\u2019t like it or simply ran out of space in the list. But we\u2019d like to hear from you so send any comments to info@hepatochem.com<\/a> or our new Bluesky account at @evoluchem.bsky.social<\/a>.<\/p>\n

Now on to the list:<\/strong><\/p>\n

Paper 1: Transforming Amino Acids into Serotonin 5\u2011HT2A Receptor Ligands Using Photochemistry<\/h3>\n

Authors: <\/strong>Joseph O. S. Beckett, Ryan Buzdygon, Steven Nguyen, Allison A. Clark, Serena S. Schalk, Lena E. H. Svanholm, Trey J. Brasher, Marc Bazin, Bruna Cuccurazzu, Adam L. Halberstadt, John D. McCorvy,* and Mark Mascal*<\/p>\n

Ref: <\/strong>J. Am. Chem. Soc.<\/em> 2025 <\/strong>ASAP<\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/jacs.5c19817<\/a><\/p>\n

Comment:<\/strong> First, it would be disingenuous for us to claim that we enjoyed any paper from 2025 more than this work that we were grateful to contribute.\u00a0 We want to thank Professor Mascal for the opportunity to contribute to the project and specifically point out the hard work of lead author Joseph Beckett.\u00a0 The Lucent360 was perfectly suited to speed up the key ring-closing reaction methodology with multi-reaction screening of wavelength for various UV LEDs, light intensity, solvents, acid additives and a library of compounds. The Lucent360 compared extremely favorably to a different commercial photoreactor that you may have heard of, cutting most reaction times from 24-48 hours down to 4 hours speeding up development.\u00a0 From there, the hard work of Mascal and team continued with scale up and conversion to new serotonin 5-HT2A agonists, bioanalytical work, animal testing to demonstrate the non-hallucinogenic activity of the new compounds.\u00a0 We look forward to seeing what\u2019s next from this work.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 2: In Crystallo Photochemistry: Reimagining Synthetic Tractability with Transparent Single-Crystalline Flasks.<\/h3>\n

Authors:\u00a0 <\/strong>Aishanee Sur and David C. Powers*<\/p>\n

Ref:<\/strong> ACS Cent. Sci.\u00a0<\/em>2025<\/strong>, 11, 6, 834\u2013842<\/em><\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/acscentsci.5c00549<\/a>.<\/p>\n

Comment:<\/strong> \u00a0\u00a0Our favorite paper this year is this work by the Powers Lab at Texas A&M.\u00a0 How does it rise above the rest?\u00a0 Simply by being an incredibly interesting idea that we knew nothing about before reading it.\u00a0 In crystallo <\/em>photochemistry is definitely a new one for us.\u00a0 For anyone looking for an introduction into a world that seems impossible, this outlook is a great place to start.\u00a0 We can\u2019t say anything any better than the authors for describing their mission:<\/p>\n

\u201cIn crystallo<\/em> photochemistry combines cryogenic synthetic photochemistry with solid-state molecular synthesis to enable the synthesis and characterization of reactive intermediates and other exotic molecular structures.\u201d<\/p>\n

We may have a half-started blog post on this paper sitting around somewhere but we could never quite do the paper justice besides just stating \u2013 \u201cread the whole thing\u201d\u00a0 So read the whole and get to the end for some \u201cPhotochemical Movies\u201d
\n\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 3: Microenvironments as an Explanation for the Mismatch between Photochemical Absorptivity and Reactivity.<\/h3>\n

Authors: <\/strong>Joshua A. Carroll, Fred Pashley-Johnson, Maciej Klein, Theresa Stephan, Ajay K. Pandey, Michael Walter, Andreas-Neil Unterreiner, and Christopher Barner-Kowollik*<\/p>\n

Ref:<\/strong> J. Am. Chem. Soc<\/em> 2025<\/strong>, 147<\/em>, 26643\u201326651.<\/p>\n

Link:<\/strong>\u00a0 https:\/\/doi.org\/10.1021\/jacs.5c06961<\/a>.<\/p>\n

Comment<\/strong>: <\/strong>A fascinating work by Professor Barner-Kowollik questioning all the things we think happen when a molecule absorbs a photon of light.<\/p>\n

\"Paper<\/a><\/strong><\/p>\n

Paper 4: Illuminating the Role of Alcohol Substrate in Nickel Photoredox Catalysis via Ground State and Transient Absorption Spectroscopy<\/h3>\n

Authors: <\/strong>Annika R. Holm, Rachel F. Wallick, Josh Vura-Weis,* and Liviu M. Mirica*<\/p>\n

Ref: <\/strong>ACS Catal.<\/em> 2025 <\/strong>ASAP.<\/p>\n

Link:<\/strong>\u00a0 https:\/\/doi.org\/10.1021\/acscatal.5c07700<\/a>.<\/p>\n

Comment:<\/strong> \u00a0\u00a0A great work by Professor Mirica and coworkers at the University of Illinois showing the benefits of the Lucent360.<\/p>\n

 <\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 5: Stereochemical Editing at Sp3-Hybridized Carbon Centers by Reversible, Photochemically Triggered Hydrogen Atom Transfer.<\/h3>\n

Authors:<\/strong> Maximilian Iglhaut and Thorsten Bach*<\/p>\n

Ref:<\/strong> Acc. Chem. Res.\u00a0<\/em>2025<\/strong>, 58, 5, 777\u2013786<\/em><\/p>\n

Link<\/strong>: https:\/\/doi.org\/10.1021\/acs.accounts.4c00830<\/a>.<\/p>\n

Comment:\u00a0 <\/strong>\u00a0We really enjoyed this review looking at stereogenic editing methods with photochemistry and HAT reactions.<\/p>\n

\"Paper<\/a><\/p>\n

Paper 6: Design and Experimental Validation of a Photocatalyst Recommender Based on a Large Language Model.<\/h3>\n

Authors:\u00a0 <\/strong>Francis Millward, Micha\u0142 Kulczykowski, Jay Badland-Shaw, Sara Szymkuc, Rajan Suraksha, Aniket Kumar Srivastawa, Violaine Manet, M\u00e1ire Griffin, Megan Bryden, Thomas Comerford, Lea H\u00e4mmerling, Aminata Mariko, Bartosz A. Grzybowski,* and Eli Zysman-Colman*<\/p>\n

Ref:<\/strong> Angewandte Chem. Int. Ed.<\/em> 2025<\/strong>.<\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1002\/anie.202514544<\/a>.<\/p>\n

Comment: <\/strong>Using a Large Language Model to predict and validate the selection of a photocatalyst.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 7: Direct C \u2500 H Lactonization of Carboxylic Acids Enabled by LMCT Photoactivation.<\/h3>\n

Authors:<\/strong> Kathryn M. Weber, Rodrigo Villanueva, Mihai V. Popescu, Grace A. Lutovsky, Samuel N. Gockel, Robert S. Paton,* and Tehshik P. Yoon*<\/p>\n

Ref:<\/strong> Angew. Chem. Int. Ed.<\/em> 2025 <\/strong>ASAP<\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1002\/anie.202515582<\/a>.<\/p>\n

Comment:\u00a0 <\/strong>A useful photochemical method for the conversion of carboxylic acids to lactones without decarboxylation.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 8: Persistent Boryl Radicals as Highly Reducing Photoredox Catalysts for Debrominative Borylations.<\/h3>\n

Authors: <\/strong>Jingjing Wu, Hui Wang, Huaquan Fang, Kevin C. Wang, Deborin Ghosh, Valerio Fasano, Adam Noble,* and Varinder K. Aggarwal*<\/p>\n

Ref<\/strong>: J. Am. Chem. Soc<\/em> 2025<\/strong>, 147<\/em>, 19450\u201319457.<\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/jacs.5c03864<\/a><\/p>\n

Comment: <\/strong>A new class of boryl-bipyridine photocatalysts.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

.<\/p>\n

Paper 9: From Tradition to Innovation: The Transition of P450 Enzyme Catalysis via Light-Driven Electron Transfer.<\/h3>\n

Authors:<\/strong> Ziyang Yin, Jiaying Ai, Jikai Gao, Xiaoyan Lin, Fuping Lu,* Hui-Min Qin,* and Shuhong Mao*<\/p>\n

Ref:<\/strong> ACS Catal.\u00a0<\/em>2025<\/strong>, 15, 15, 13412\u201313427<\/em><\/p>\n

Link<\/strong>: https:\/\/doi.org\/10.1021\/acscatal.5c02655<\/a>.<\/p>\n

Comment:\u00a0 <\/strong>If you write a review combining light, cytochrome P450s and porphryins it\u2019s a guarantee that we\u2019ll read your paper and you\u2019ll make our year end list.<\/p>\n

\"Paper<\/a><\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Paper 10: Photochemical Manganese-Catalyzed [2 + 2 + 2] Cycloaddition Reactions.<\/h3>\n

Authors:<\/strong> Benedikt N. Baumann, Phong Dam, Jabor Rabeah, Christoph Kubis, Angelika Bru\u0308ckner,* Haijun Jiao,* and Marko Hapke*<\/p>\n

Ref:<\/strong> ACS Catal.<\/em> 2025<\/strong>, 15<\/em>, 5718\u20135730.<\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/acscatal.5c00349<\/a><\/p>\n

Comment: <\/strong>Another great work from the Hapke group using photochemistry, high temperatures and the Lucent360 for cyclotrimerization reactions.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 11: Visible Light Promoted Alkenyl C \u2212 H Bond Addition to Dienes and Aldehydes for the Synthesis of Frameworks Relevant to Polyketide Natural Products.<\/h3>\n

Authors: <\/strong>Shohei Ohno, Ramsey M. Goodner, Danielle N. Confair, Brandon Q. Mercado, and Jonathan A. Ellman*<\/p>\n

Ref:<\/strong> ACS Catal.<\/em> 2025<\/strong>.<\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/acscatal.5c05961<\/a>.<\/p>\n

Comment: <\/strong>The fourth Lucent360 paper from this year on our list.\u00a0 Seriously check out the Lucent360.\u00a0 This work by the Ellman group at Yale just qualified for the year with publication online on Christmas day 2025 using photochemistry to make some polyketide natural products.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 12: Magnetic Stirring May Cause Irreproducible Results in Chemical Reactions.<\/h3>\n

Authors: <\/strong>Vera A. Cherepanova, Evgeniy G. Gordeev, and Valentine P. Ananikov*<\/strong><\/p>\n

Ref:<\/strong> JACS Au\u00a0<\/em>2025<\/strong>, 5, 8, 3789\u20133798<\/em><\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/jacsau.5c00412<\/a>.<\/p>\n

Comment: <\/strong>The only non-photochemistry paper on the list but it remains highly relevant.\u00a0 A very detailed look at the effects of stirring on the irreproducibility of all chemical reactions.\u00a0 If you missed this highly read paper this year, it\u2019s definitely worth your time.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 13: Pyridoxal-Inspired Photo-Decarboxylase Catalysis: Photochemical Decarboxylation of Unprotected Amino Acids.<\/h3>\n

Authors: <\/strong>Dong-Hang Tan, Agniva Das, Vincent Huang, Timothy D. Schoch, Abubakar Lawal Mohammed, Jeffrey M. Lipshultz<\/p>\n

Ref:<\/strong> Angew. Chemie – Int. Ed.<\/em> 2025<\/strong>, 64<\/em> (14).<\/p>\n

Link: <\/strong>https:\/\/doi.org\/10.1002\/anie.202424843<\/a>.<\/p>\n

Comment: <\/strong>We\u2019ll take a moment to highlight the first independent paper for Professor Lipshultz at Stony Brook which also uses a few EvoluChem LEDs.\u00a0 Congratulations.<\/p>\n

\"Paper<\/a><\/p>\n

\u00a0<\/strong><\/p>\n

 <\/p>\n

Paper 14: A Modular Synthesis of Azetidines from Reactive Triplet Imine Intermediates Using an Intermolecular Aza Patern\u00f2 \u2013 B\u00fcchi Reaction.<\/h3>\n

Authors: <\/strong>Benedict A. Williams, Michael J. Tilby, Nicholas A. Parker, Mycah R. Uehling, J. Caleb Hethcox, Dipannita Kalyani & Michael C. Willis<\/p>\n

Ref:<\/strong> Nature Catalysis 8, pages 939\u2013947 (<\/em>2025<\/strong>)<\/em><\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1038\/s41929-025-01405-7<\/a><\/p>\n

Comment: <\/strong>We really enjoyed this work in Nature Catalysis from the Willis lab at the University of Oxford looking at new methods for making azetidines using the PhotoRedox Box.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 15: Carbonylative Ring Expansion of Cyclic Carboxylic Acids.<\/h3>\n

Authors: <\/strong>Hiroki Shimono, Mayu Kusakabe, Kazunori Nagao,* and Hirohisa Ohmiya*<\/strong><\/p>\n

Ref<\/strong>: J. Am. Chem. Soc. <\/em>2025<\/strong>, 147, 50, 45884\u201345892<\/em><\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/jacs.5c08640<\/a><\/p>\n

Comment: <\/strong>A very cool method for ring expansion and molecular editing techniques to turn cyclic carboxylic acids into larger heterocycles which just so happens to use the PhotoRedox Box Duo for the photochemistry. Great work!<\/p>\n

\"Paper<\/a><\/p>\n

Paper 16: A Manganese (I) Complex with a 190 Ns Metal- to-Ligand Charge Transfer Lifetime.<\/h3>\n

Authors:<\/strong> Sandra Kronenberger, Robert Naumann, Christoph F\u00f6rster, Nathan R. East, Jan Klett and Katja Heinze*<\/p>\n

Ref:<\/em><\/strong> Nature Communications 16, Article Number: 7850 (<\/em>2025<\/strong>)<\/em><\/p>\n

Link:<\/strong>\u00a0 https:\/\/www.nature.com\/articles\/s41467-025-63225-4<\/a><\/p>\n

Comment: <\/strong>An inexpensive metal photocatalyst doing things we expect to be more likely of its precious metal relatives.<\/p>\n

\"Paper<\/a><\/p>\n

Paper 17: Energy Transfer-Enabled Enantioselective Photocyclization Using a Privileged Al \u2013 Salen Catalyst.<\/h3>\n

Authors: <\/strong>Julia Soika, Carina Onneken, Thorben Wiegmann, Timo St\u00fcnkel, Tobias Morack, Leander Lindfeld, Marian Hebenbrock, Christian M\u00fcck-Lichtenfeld, Johannes Neugebauer* and Ryan Gilmour*<\/p>\n

Ref:<\/strong> Nature Chemistry volume 17, pages 1383\u20131390 (<\/em>2025<\/strong>)<\/em><\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1038\/s41557-025-01857-1<\/a>.<\/p>\n

Comment: <\/strong>Another work looking at finding alternatives to precious metals with common metal complexes.<\/p>\n

\"Paper<\/a><\/p>\n

Paper 18: A Unified Approach to Meta-Selective Methylation, Mono-, Di- and Trifluoromethylation of Arenes<\/h3>\n

Authors:<\/strong> Elisa Y. Lai, Lutz Ackermann, and Magnus J. Johansson<\/p>\n

Ref:<\/strong>\u00a0 Chemical Science<\/em> 16: 8478\u201386<\/p>\n

Link: <\/strong>https:\/\/doi.org\/10.1039\/d5sc01367d<\/a>.<\/p>\n

Comment: <\/strong>One last Lucent360 paper for the year, this one from the AstraZeneca Gothenburg looking at new methods for quickly accessing substituted arenes.<\/p>\n

\"Paper<\/a><\/p>\n

Paper 19: Exploring the Increased Activity of the Blue Light-Dependent Photoenzyme Fatty Acid Photodecarboxylase under Violet Light.<\/h3>\n

Authors: <\/strong>Harry J. Spacey, Daniel Healy, Jason M. D. Kalapothakis, Junfeng Ma, Michiyo Sakuma, Perdita E. Barran, Derren J. Heyes,* and Nigel S. Scrutton*<\/p>\n

Ref<\/strong>: ACS Catal.\u00a0<\/em>2025<\/strong>, 15, 8, 6088\u20136097<\/em><\/p>\n

Link: <\/strong>https:\/\/doi.org\/10.1021\/acscatal.4c07757<\/a>.<\/p>\n

Comment: <\/strong>A very interesting look at the effect of wavelength of light on a naturally occurring photoenzyme and the implications for photodecarboxylation.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

 <\/p>\n

Paper 20: Polymers and Light: A Love\u2013Hate Relationship.<\/h3>\n

Authors: <\/strong>M. A. Sachini, N. Weerasinghe, Tochukwu Nwoko and Dominik Konkolewicz<\/p>\n

Ref:<\/strong> Chem. Sci., <\/em>2025<\/strong>, 16, 5326-5352<\/em><\/p>\n

Link:<\/strong> https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2025\/sc\/d5sc00997a<\/a><\/p>\n

Comment: <\/strong>A good (open access) review of some experimental methods and challenges in photopolymerization reactions.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

Paper 21: RAFT with Light: A User Guide to Using Thiocarbonylthio Compounds in Photopolymerizations.<\/h3>\n

Authors:<\/strong> Magdalena A. Beres, Cyrille Boyer, Matthias Hartlieb, Dominik Konkolewicz, Greg G. Qiao, Brent S. Sumerlin and S\u00e9bastien Perrier*<\/p>\n

Ref:<\/strong> ACS Polym. Au\u00a0<\/em>2025<\/strong>, 5, 3, 184\u2013213<\/em><\/p>\n

Link: <\/strong>https:\/\/doi.org\/10.1021\/acspolymersau.4c00101<\/a><\/p>\n

Comment:\u00a0\u00a0 <\/strong>A detailed look at selecting the appropriate wavelength for your photopolymerizations.<\/p>\n

\"Paper<\/a><\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

Paper 22: Visible Light-Triggered Depolymerization of Commercial Polymethacrylates.<\/h3>\n

Authors:<\/strong> Hyun Suk Wang, Mikhail Agrachev, Hongsik Kim, Nghia P. Truong, Tae-Lim Choi, Gunnar Jeschke, and Athina Anastasaki<\/p>\n

Ref:<\/strong> Science 387 2<\/strong><\/em>025<\/strong>, 874-880<\/em><\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1126\/science.adr1637<\/a>.<\/p>\n

Comment:\u00a0 \u00a0<\/strong>And to end this run of polymerization papers, a photochemical method for taking them back apart.<\/p>\n

 <\/p>\n

 <\/p>\n

Paper 23: Precision Photochemistry: Every Photon Counts.<\/h3>\n

Authors:<\/strong> Fred Pashley-Johnson, Xingyu Wu, Joshua A. Carroll, Sarah L. Walden, Hendrik Frisch,* Andreas-Neil Unterreiner,* Filip E. Du Prez,* Hans-Achim Wagenknecht,* Javier Read de Alaniz,* Ben L. Feringa,* Alexander Heckel,* and Christopher Barner-Kowollik*<\/p>\n

Ref:<\/strong> Angew. Chemie Int. Ed.<\/em> 64, 2025<\/strong>.<\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1002\/anie.202502651<\/a><\/p>\n

Comment: \u00a0<\/strong>A thorough perspective from a full lineup of photochemistry all-stars on the goals and objectives for photochemistry efficiently and effectively.<\/p>\n

\"Paper<\/a><\/p>\n

Paper 24: Breaking Kasha\u2019s Rule to Enable Higher Reactivity in Photoredox Catalysis<\/h3>\n

Author:<\/strong> Bj\u00f6rn Pfund* and Oliver S. Wenger*<\/p>\n

Ref:<\/strong> J. Am. Chem. Soc.\u00a0<\/em>2025<\/strong>, 147, 30, 26477\u201326485<\/em><\/p>\n

Link: <\/strong>https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c06115<\/a><\/p>\n

Comment\u00a0:<\/strong>\u00a0 Another photochemistry paper challenging the rules that we all believe to be true<\/p>\n

\"Paper<\/a>\u00a0<\/strong><\/p>\n

Paper 25: New Opportunities to Access Fluorinated Molecules Using Organophotoredox Catalysis via C(Sp3)-F Bond Cleavage.<\/h3>\n

Authors: <\/strong>Sourav Roy* and Tatiana Besset*<\/p>\n

Ref:<\/strong> JACS Au\u00a0<\/em>2025<\/strong>, 5, 2, 466\u2013485<\/em><\/p>\n

Link:<\/strong> https:\/\/doi.org\/10.1021\/jacsau.4c01158<\/a>.<\/p>\n

Comment\u00a0:\u00a0 <\/strong>The last review on the list.\u00a0 If you are interested in fluorinating things, check out this review for a summary of photoredox methods big and small for sticking and F on your molecule.<\/p>\n

\"Paper<\/a><\/strong><\/p>\n

Paper 26: Concurrent Linear Deracemization of Secondary Benzylic Alcohols via Simultaneous Photocatalysis and Whole-Cell Biocatalysis<\/h3>\n

Authors: <\/strong>W. Y. Wylan Wong, Stephen Wallace,* and Craig P. Johnston*<\/p>\n

Ref:\u00a0 <\/strong>ACS Catal.\u00a0<\/em>2025<\/strong>, 15, 17, 15195\u201315210<\/em><\/p>\n

Link:<\/strong>\u00a0 https:\/\/doi.org\/10.1021\/acscatal.5c04974<\/a>.<\/p>\n

Comment: <\/strong>We\u2019ll end this year\u2019s list with a bonus paper, this very cool example of photochemistry in whole cells.\u00a0 This work took advantage of the PhotoRedox Box, some EvoluChem LEDs, a water-soluble photocatalysis and some whole cells to combine photocatalysis and biocatalysis.\u00a0 Expect to hear more HepatoChem about biocatalysis in 2026, as our soon to be launched plate photoreactor will be ideal for this type of experiment.<\/p>\n

\"Paper<\/a><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

Thank you to everyone for reading this far.\u00a0\u00a0 What did we miss?\u00a0 What\u2019s your favorite paper of the year.<\/h4>\n

Let us know what you think at info@hepatochem.com<\/a><\/span><\/h4>\n

or our new Bluesky account at @evoluchem.bsky.social<\/a><\/span>.<\/h4>\n","protected":false},"excerpt":{"rendered":"

Our 25 favorite photochemistry papers from 2025 \u00a0Happy New Year from all of us at HepatoChem. \u00a0Before we move forward into another great year, let\u2019s take a look back at the past year in photochemistry.\u00a0 \u00a02025 gave us a ton of interesting photochemistry papers, new products, fun ideas and expanded the areas where photochemistry is […]<\/p>\n","protected":false},"author":1,"featured_media":24757,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[480,478],"tags":[],"class_list":["post-24755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-article","category-scientific-literature"],"yoast_head":"\n2025 Photochemistry Year in Review<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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