Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#\\\/schema\\\/person\\\/e095b8d6d9795de228233250261c2cfd\"},\"headline\":\"Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes\",\"datePublished\":\"2018-01-01T23:12:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/\"},\"wordCount\":113,\"publisher\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/hepatochem.com\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Screen-Shot-2020-09-01-at-7.24.52-PM.png\",\"articleSection\":[\"Featured Article\"],\"inLanguage\":\"en-EU\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/\",\"url\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/\",\"name\":\"Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/hepatochem.com\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Screen-Shot-2020-09-01-at-7.24.52-PM.png\",\"datePublished\":\"2018-01-01T23:12:58+00:00\",\"inLanguage\":\"en-EU\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-EU\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\\\/#primaryimage\",\"url\":\"https:\\\/\\\/hepatochem.com\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Screen-Shot-2020-09-01-at-7.24.52-PM.png\",\"contentUrl\":\"https:\\\/\\\/hepatochem.com\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Screen-Shot-2020-09-01-at-7.24.52-PM.png\",\"width\":374,\"height\":225,\"caption\":\"A diagram of the process of synthesis of blue leds.\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#website\",\"url\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/\",\"name\":\"HepatoChem\",\"description\":\"Reinventing Chemistry for Life Sciences\",\"publisher\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-EU\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#organization\",\"name\":\"HepatoChem\",\"url\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-EU\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/i0.wp.com\\\/xn8.6f7.myftpupload.com\\\/wp-content\\\/uploads\\\/2019\\\/12\\\/HepatoChem-logo-lowres.png?fit=500%2C89&ssl=1\",\"contentUrl\":\"https:\\\/\\\/i0.wp.com\\\/xn8.6f7.myftpupload.com\\\/wp-content\\\/uploads\\\/2019\\\/12\\\/HepatoChem-logo-lowres.png?fit=500%2C89&ssl=1\",\"width\":500,\"height\":89,\"caption\":\"HepatoChem\"},\"image\":{\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/evoluchem\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/2420256\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/#\\\/schema\\\/person\\\/e095b8d6d9795de228233250261c2cfd\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-EU\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c957a93c7d0c8dd066483ae6aed9fb20b222db3695bbe7f027a1baa409d44446?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c957a93c7d0c8dd066483ae6aed9fb20b222db3695bbe7f027a1baa409d44446?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c957a93c7d0c8dd066483ae6aed9fb20b222db3695bbe7f027a1baa409d44446?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"url\":\"https:\\\/\\\/hepatochem.com\\\/euro\\\/author\\\/admin\\\/\"}]}<\/script>\n","yoast_head_json":{"title":"Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/","twitter_misc":{"Written by":"admin","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/#article","isPartOf":{"@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/"},"author":{"name":"admin","@id":"https:\/\/hepatochem.com\/euro\/#\/schema\/person\/e095b8d6d9795de228233250261c2cfd"},"headline":"Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes","datePublished":"2018-01-01T23:12:58+00:00","mainEntityOfPage":{"@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/"},"wordCount":113,"publisher":{"@id":"https:\/\/hepatochem.com\/euro\/#organization"},"image":{"@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/#primaryimage"},"thumbnailUrl":"https:\/\/hepatochem.com\/wp-content\/uploads\/2020\/09\/Screen-Shot-2020-09-01-at-7.24.52-PM.png","articleSection":["Featured Article"],"inLanguage":"en-EU"},{"@type":"WebPage","@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/","url":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/","name":"Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes","isPartOf":{"@id":"https:\/\/hepatochem.com\/euro\/#website"},"primaryImageOfPage":{"@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/#primaryimage"},"image":{"@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/#primaryimage"},"thumbnailUrl":"https:\/\/hepatochem.com\/wp-content\/uploads\/2020\/09\/Screen-Shot-2020-09-01-at-7.24.52-PM.png","datePublished":"2018-01-01T23:12:58+00:00","inLanguage":"en-EU","potentialAction":[{"@type":"ReadAction","target":["https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/"]}]},{"@type":"ImageObject","inLanguage":"en-EU","@id":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/#primaryimage","url":"https:\/\/hepatochem.com\/wp-content\/uploads\/2020\/09\/Screen-Shot-2020-09-01-at-7.24.52-PM.png","contentUrl":"https:\/\/hepatochem.com\/wp-content\/uploads\/2020\/09\/Screen-Shot-2020-09-01-at-7.24.52-PM.png","width":374,"height":225,"caption":"A diagram of the process of synthesis of blue leds."},{"@type":"WebSite","@id":"https:\/\/hepatochem.com\/euro\/#website","url":"https:\/\/hepatochem.com\/euro\/","name":"HepatoChem","description":"Reinventing Chemistry for Life Sciences","publisher":{"@id":"https:\/\/hepatochem.com\/euro\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/hepatochem.com\/euro\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-EU"},{"@type":"Organization","@id":"https:\/\/hepatochem.com\/euro\/#organization","name":"HepatoChem","url":"https:\/\/hepatochem.com\/euro\/","logo":{"@type":"ImageObject","inLanguage":"en-EU","@id":"https:\/\/hepatochem.com\/euro\/#\/schema\/logo\/image\/","url":"https:\/\/i0.wp.com\/xn8.6f7.myftpupload.com\/wp-content\/uploads\/2019\/12\/HepatoChem-logo-lowres.png?fit=500%2C89&ssl=1","contentUrl":"https:\/\/i0.wp.com\/xn8.6f7.myftpupload.com\/wp-content\/uploads\/2019\/12\/HepatoChem-logo-lowres.png?fit=500%2C89&ssl=1","width":500,"height":89,"caption":"HepatoChem"},"image":{"@id":"https:\/\/hepatochem.com\/euro\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/evoluchem","https:\/\/www.linkedin.com\/company\/2420256"]},{"@type":"Person","@id":"https:\/\/hepatochem.com\/euro\/#\/schema\/person\/e095b8d6d9795de228233250261c2cfd","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-EU","@id":"https:\/\/secure.gravatar.com\/avatar\/c957a93c7d0c8dd066483ae6aed9fb20b222db3695bbe7f027a1baa409d44446?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c957a93c7d0c8dd066483ae6aed9fb20b222db3695bbe7f027a1baa409d44446?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c957a93c7d0c8dd066483ae6aed9fb20b222db3695bbe7f027a1baa409d44446?s=96&d=mm&r=g","caption":"admin"},"url":"https:\/\/hepatochem.com\/euro\/author\/admin\/"}]}},"jetpack_featured_media_url":"https:\/\/hepatochem.com\/wp-content\/uploads\/2020\/09\/Screen-Shot-2020-09-01-at-7.24.52-PM.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/posts\/25634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/comments?post=25634"}],"version-history":[{"count":0,"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/posts\/25634\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/media\/25635"}],"wp:attachment":[{"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/media?parent=25634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/categories?post=25634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hepatochem.com\/euro\/wp-json\/wp\/v2\/tags?post=25634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

{"id":25634,"date":"2018-01-01T16:12:58","date_gmt":"2018-01-01T23:12:58","guid":{"rendered":"https:\/\/hepatochem.com\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/"},"modified":"2018-01-01T16:12:58","modified_gmt":"2018-01-01T23:12:58","slug":"photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes","status":"publish","type":"post","link":"https:\/\/hepatochem.com\/euro\/photoredox-synthesis-of-arylhydroxylamines-from-carboxylic-acids-and-nitrosoarenes\/","title":{"rendered":"Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes"},"content":{"rendered":"

\n $\"\"$ Abstract<\/strong><\/p>\n

Hydroxylamines are found in biologically active compounds and serve as building blocks for the preparation of nitrogen-containing molecules. Here the direct conversion of carboxylic acids into the corresponding alkylhydroxylamines using organo-photoredox catalysis is reported. The process relies in the generation of alkyl radicals via photoinduced oxidation-decarboxylation and their following reaction with nitrosoarenes. We have successfully applied this method to the late-stage modification of complex and biologically active acids and applied it in novel radical cascade processes.<\/p>\n

Authors:<\/strong> Jacob Davies, Lucrezia Angelini, Mohammed A. Alkhalifah, Laia Malet Sanz, Nadeem S. Sheikh*, Daniele Leonori<\/a>“‰ *<\/p>\n

Link:<\/strong> https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0036-1591744<\/a><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"