{"id":25602,"date":"2019-09-01T10:46:45","date_gmt":"2019-09-01T17:46:45","guid":{"rendered":"https:\/\/hepatochem.com\/carbon-heteroatom-cross-coupling-via-an-electronically-excited-nickel-ii-complex\/"},"modified":"2019-09-01T10:46:45","modified_gmt":"2019-09-01T17:46:45","slug":"carbon-heteroatom-cross-coupling-via-an-electronically-excited-nickel-ii-complex","status":"publish","type":"post","link":"https:\/\/hepatochem.com\/euro\/carbon-heteroatom-cross-coupling-via-an-electronically-excited-nickel-ii-complex\/","title":{"rendered":"Carbon-Heteroatom Cross-Coupling via an Electronically Excited Nickel (II) Complex"},"content":{"rendered":"<p><!DOCTYPE html PUBLIC \"-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\" \"http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\"><br \/>\n<html><body><\/p>\n<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;3.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;]<div id=\"attachment_8313\" style=\"width: 279px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-8313\" class=\"size-full wp-image-8313\" src=\"https:\/\/hepatochem.com\/wp-content\/uploads\/2019\/09\/Screen-Shot-2020-09-01-at-1.52.27-PM.png\" alt=\"\" width=\"269\" height=\"203\"><p id=\"caption-attachment-8313\" class=\"wp-caption-text\">&#8220;The reaction was then sealed with a plastic screw cap and placed in a HepatoChem reactor on a stir plate and irradiated for 18 hours with a 34W blue LED and the internal fan was purposely left off to maintain a slightly elevated temperature of ~35 \u00b0C.&#8221;<\/p><\/div><\/p>\n<p><strong>Abstract<\/strong>\n<\/p>\n<div>While carbon-heteroatom cross coupling reactions have been extensively studied, many methods are specific and limited to a set of substrates or functional groups. Reported here is a method that allows for C-O, C-N and C-S cross coupling reactions under one general methodology. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel (II) complex, is responsible for the key reductive elimination step that couples aryl halides to 1\u00b0 and 2\u00b0 alcohols, anilines, thiophenols, carbamates and sulfonamides.<\/div>\n<div><\/div>\n<div><strong>Authors: <a class=\"normal-link\" title=\"\" href=\"mailto:jeffrey.johannes@astrazeneca.com\" target=\"\" rel=\"noopener noreferrer\">jeffrey.johannes@astrazeneca.com<\/a><\/strong><\/div>\n<div><\/div>\n<div><strong>Link: <a href=\"https:\/\/chemrxiv.org\/articles\/Carbon-Heteroatom_Cross-Coupling_via_an_Electronically_Excited_Nickel_II_Complex\/9736049\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/chemrxiv.org\/articles\/Carbon-Heteroatom_Cross-Coupling_via_an_Electronically_Excited_Nickel_II_Complex\/9736049<\/a><\/strong><\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract While carbon-heteroatom cross coupling reactions have been extensively studied, many methods are specific and limited to a set of substrates or functional groups. Reported here is a method that allows for C-O, C-N and C-S cross coupling reactions under one general methodology. We propose that an energy transfer pathway, in which an iridium photosensitizer [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":25603,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[caption id=\"attachment_8313\" align=\"alignright\" width=\"269\"]<img class=\"size-full wp-image-8313\" src=\"https:\/\/hepatochem.com\/wp-content\/uploads\/2019\/09\/Screen-Shot-2020-09-01-at-1.52.27-PM.png\" alt=\"\" width=\"269\" height=\"203\" \/> \"The reaction was then sealed with a plastic screw cap and placed in a HepatoChem reactor on a stir plate and irradiated for 18 hours with a 34W blue LED and the internal fan was purposely left off to maintain a slightly elevated temperature of ~35 \u00b0C.\"[\/caption]<p><strong>Abstract<\/strong><\/p><div>While carbon-heteroatom cross coupling reactions have been extensively studied, many methods are specific and limited to a set of substrates or functional groups. Reported here is a method that allows for C-O, C-N and C-S cross coupling reactions under one general methodology. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel (II) complex, is responsible for the key reductive elimination step that couples aryl halides to 1\u00b0 and 2\u00b0 alcohols, anilines, thiophenols, carbamates and sulfonamides.<\/div><div>\u00a0<\/div><div><strong>Authors: <a class=\"normal-link\" title=\"\" href=\"mailto:jeffrey.johannes@astrazeneca.com\" target=\"\" rel=\"noopener noreferrer\">jeffrey.johannes@astrazeneca.com<\/a><\/strong><\/div><div>\u00a0<\/div><div><strong>Link: <a href=\"https:\/\/chemrxiv.org\/articles\/Carbon-Heteroatom_Cross-Coupling_via_an_Electronically_Excited_Nickel_II_Complex\/9736049\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/chemrxiv.org\/articles\/Carbon-Heteroatom_Cross-Coupling_via_an_Electronically_Excited_Nickel_II_Complex\/9736049<\/a><\/strong><\/div>","_et_gb_content_width":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[680],"tags":[],"class_list":["post-25602","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Carbon-Heteroatom Cross-Coupling via an Electronically Excited Nickel (II) Complex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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