Abstract
Hydroxylamines are found in biologically active compounds and serve as building blocks for the preparation of nitrogen-containing molecules. Here the direct conversion of carboxylic acids into the corresponding alkylhydroxylamines using organo-photoredox catalysis is reported. The process relies in the generation of alkyl radicals via photoinduced oxidation-decarboxylation and their following reaction with nitrosoarenes. We have successfully applied this method to the late-stage modification of complex and biologically active acids and applied it in novel radical cascade processes.
Authors: Jacob Davies, Lucrezia Angelini, Mohammed A. Alkhalifah, Laia Malet Sanz, Nadeem S. Sheikh*, Daniele Leonori“‰ *
Link: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1591744
